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Given the following: You have a [hormone]plasma = 1 µM, which is 60 %

 

 

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Given the following: You have a [hormone]plasma = 1 µM, which is 60 % bound by plasma proteins.  The liver enzyme responsible for metabolizing this hormone does so at a constant rate per [hormone]; i.e., the enzyme follows first-order kinetics.  The decay constant, kel, is 0.578.  Calculate the t1/2 and then determine the [hormone]plasma  6 half-lives later.  Fill in the following table below.

 

Is this hormone more likely to be H2O-soluble or lipid-soluble?  ____________________

 

t1/2 = __________________

 

 

Number of half-lives Time passed [Hormone]plasma
1  

 

 
2  

 

 
3  

 

 
4  

 

 
5  

 

 
6  

 

 

 

Assume no significant further hormone synthesis and secretion is occurring at this time.

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