Answer the following questions in regards to the paper “Sirtuins, epigenetics and longevity.”
1. Briefly, without re-wrting the paper, describe how yeast and mammalian sirtuins are conserved across the divergent species.
2. Choose one surtuin that is conserved between yeast and mammals and describe in detail its mechanism of action and how that effects longevity.
3. How does calorie restriction affect DNA methylation leading to an increase in longevity?
4. Descriibe briefly the general function of micro RNAs.
5. Using your own words, describe the role of miR-34, SIRT1 and p53 in aging.
6. In your own words, what are the overall conclusions of the paper?
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